R-( )- -lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1
نویسندگان
چکیده
Michaela Artwohl, Kathrin Muth, Karin Kosulin, Rainer de Martin, Thomas Hölzenbein, Georg Rainer, Angelika Freudenthaler, Nicole Huttary, Leopold Schmetterer, Werner K. Waldhäusl, and Sabina M. Baumgartner-Parzer Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna; Division of Molecular Microbiology and Development of Genetic Diagnostics, Children’s Cancer Research Institute; Center for Biomolecular Medicine and Pharmacology, Institute of Vascular Biology and Thrombosis Research; Department of Surgery, Division of Vascular Surgery; Department of Ophthalmology; Clinical Institute of Pathology; and Center for Biomedical Techniques and Physics, Medical University of Vienna, Vienna, Austria
منابع مشابه
R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1.
Lipoic acid was recently demonstrated to improve endothelial dysfunction or retinopathy not only in rats but also in diabetic patients. We tested the hypothesis that R-(+)-alpha-lipoic acid (LA) directly affects human endothelial cell (EC) function (e.g., apoptosis, proliferation, and protein expression), independent of the cells' vascular origin. Macrovascular EC (macEC), isolated from umbilic...
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